Cookies make it easier for us to provide you with our services. With the usage of our services you permit us to use cookies.
More information

  • USP 4 Header

Innovative features

For improved Flow-Through Testing.

Standardized cell head

The new cell head fits all offered cell bodies and thus enables a faster assembly of cells while offering lower purchasing costs (needed only 1x per system). Faster tube mounting is also possible through a quick lock in the cell head.

Increased leak-tightness

Due to reducing the number of seals to 3 pieces per cell and using flat seals with an increased sealing surface, the process safety can be heightened.

Optimized cell bodies & individual cell heating

The reduction of the cell body provides a better heating and faster preparation of cells. Each cell can be heated individually via a rotary switch.

Compact & corrosion-resistant housing

The smaller footprint with clear arrangement of cells in one line saves laboratory space and offers a perfect visual control of the cells at all times. In addition, the tube organizer on the back of the device prevents mixing up the cell tubes.

Easier cleaning

Due to the 3-way-valve for water emptying on the back of the device, the water bath can be cleaned much easier. In addition, simple water control is possible with the water level pointer (colour coding) and the two openings for PT 100 sensors on the device cover.
  • Standardized cell head

    The new cell head fits all offered cell bodies and thus enables a faster assembly of cells while offering lower purchasing costs (needed only 1x per system). Faster tube mounting is also possible through a quick lock in the cell head.
  • Increased leak-tightness

    Due to reducing the number of seals to 3 pieces per cell and using flat seals with an increased sealing surface, the process safety can be heightened.
  • Optimized cell bodies & individual cell heating

    The reduction of the cell body provides a better heating and faster preparation of cells. Each cell can be heated individually via a rotary switch.
  • Compact & corrosion-resistant housing

    The smaller footprint with clear arrangement of cells in one line saves laboratory space and offers a perfect visual control of the cells at all times. In addition, the tube organizer on the back of the device prevents mixing up the cell tubes.
  • Easier cleaning

    Due to the 3-way-valve for water emptying on the back of the device, the water bath can be cleaned much easier. In addition, simple water control is possible with the water level pointer (colour coding) and the two openings for PT 100 sensors on the device cover.


    Highlights

    The highlights of the new

    USP 4 Flow-Through Cell DFZ II

    The new ERWEKA flow-through cell tester DFZ II can be used for various applications thanks to its wide range of available cell types, e.g. for testing poorly soluble products or low-dose formulations with sustained release.

    Innovations as the new cell design with increased leak-tightness and the optimized tubing system with quick locks allow a fast preparation and implementation of dissolution tests. The new leaner cell bodies ensure an improved cell warming and can be heated individually. All USP 4 DFZ II systems can be easily controlled with the Disso.NET USP 4 dissolution software via a controller.


    Zellendesign

    New improved

    Cell design

    Accompanying our flow-through systems, we offer a variety of different cells with a new improved design for different purposes - from the standard tablet cell to granulate & powder cells to cells for implants, suppositories and stents.

    The new standardized cell head fits all offered cell bodies and facilitates along with the new standardized flat seals (only 3 pieces per cell: connection, head and heating jacket) handling and assembly of the cells. The optimized cell bodies with decreased cell wall thickness guarantee an improved cell heating.

    Thanks to this new cell concept, the cells can be mounted easier to the new flow-through tester DFZ II and thus enable a faster preparation and performance of dissolution tests.


    Different USP 4 cells available

    Different cells for different purposes available - e. g. for implants, granulates & powders, suppositories, stants, cells with creme adapter or with a dialysis adapter.

    • Tablet cell 12,00 mm

    • Tablet cell 22,6 mm

    • Granulate & Powder cell

    • Implant cell

    • Suppository cell

    • Stent cell

    • Tablet cell 22.6 mm with dialysis adapter

    • Tablet cell 22.6 mm with cream adapter

    • Tablet cell 22.6 mm with glass beads

    • Tablet cell 22.6 mm with glass beads


    Disso.NET USP 4

    Disso.NET USP 4

    Full dissolution software solution for the Flow-Through Cell

    The ERWEKA Disso.NET USP 4 Software is the perfect companion for our USP 4 systems. The software takes over full control of our USP 4 systems and offers support of all USP/EP dissolution cells used in these systems. It also supports cells for special applications (e.g. cell with cream adapter) and visual guides for formulation placing in the respective cells.

    The software includes an easy to handle method editor for comfortable programming of dissolution methods (for highest safety in GMP environment). Our audit trail also generates detailed protocols of all events and times and thus enables tracing changes at any time. After finishing the dissolution test, Disso.NET USP 4 creates comprehensive reports (as PDF-files) and can export all results in various formats (e.g. as XML-file).


    USP 4 Systems

    Adapted individually to your needs.

    • USP 4 Stand-Alone System

      USP 4 Stand-Alone System

      Easy entry into USP 4 dissolution testing

      The ERWEKA stand-alone flow-through cell system is perfect for performing simple release tests with manual sampling. Therefore, the new flow-through cell tester DFZ II offers in a system with the ERWEKA piston pump HKP 720 and the ERWEKA heater DH 2000i an easy entry into testing with USP 4 systems for a small budget.

      The stand-alone system consists of:

      • Piston pump HKP 720
      • Flow-through cell DFZ II + heater DH 2000i
    • USP 4 Open Offline System

      USP 4 Open Offline System

      Infinite media testing and sampling

      The open ERWEKA offline flow-through cell system is the perfect solution for testing poorly soluble products that need unlimited amounts of fresh media to dissolve.

      With the ERWEKA sample collector FRL 724 representative samples are taken over a certain period for later analysis (up to 18 sampling intervals possible).

      The system configuration comprises:

      • Piston pump HKP 720
      • Flow-through cell DFZ II + heater DH 2000i
      • Sample collector FRL 724
      • Controller with Disso.NET USP 4 software
      • One or more medium reservoirs
    • USP 4 Closed Offline System

      USP 4 Closed Offline System

      Comprehensive long-term testing

      The closed ERWEKA offline flow-through cell system is excellently suited for testing low-dose formulations with sustained release (e.g. implants). It allows performing comprehensive long-term dissolution tests with small media volumes.

      The system configuration consists of:

      • Piston pump HKP 720
      • Peristaltic pump IPC 8
      • Flow-through cell DFZ II + heater DH 2000i
      • Media transfer station LMT 2
      • Sample collector FRL 724
      • Controller with Disso.NET USP 4 software


    LMT 2

    LMT 2

    Easy media transfer

    With the compact ERWEKA media transfer station LMT 2 a closed loop for performing long-term dissolution tests according to USP 4 can be easily created. The LMT 2 is therefore used as a medium reservoir and ensures an optimal media mixing and distribution through the whole release test.

    The optimized tubing system with a new tube holder and rotatable bottle caps (safety caps) makes handling easier and saves valuable laboratory space.


    Gallery

    Get an impression of the ERWEKA USP 4 DFZ ll Flow-Through Cell System.


    Download

    Our Brochure.

    USP 4 DFZ ll Brochure

    USP 4 DFZ ll Brochure

    Download our brochure for more in-depth information.

    Download